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lunesta The applicant has also analysed the effect of gender, race, and weight on the pharmacokinetics of eszopiclone and found no meaningful differences .
Pharmacokinetic interaction studies The potential of eszopiclone to inhibit human liver CYP450 isoforms 1A2, 2A6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4 was determined in study 190-518 in cryopreserved human hepatocytes in the presence and absence lunesta of standard probe substrates .
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Table 10: Summary of in vivo drug-drug interaction studies Olanzapine 10 mg Four arm, Pbo; E; O; E + O; four No PK interaction day dosing n = 40 Significant potentiation impairment 3 hrs postdose Four arm, Pbo, lunesta erowid lunesta birth control side effects eszopiclona 2 mg uso lunesta discount lunesta E; L; E + L; three Reduction of 23% in day dosing n = 36 coadministration DSST not quite additive Paroxetine 20 mg Four arm, Pbo, E; P; E + P; three No PK or PD interaction day dosing n = 40 Warfarin 25 mg Four arm, Pbo, E; W; E + W; five No PK or PD interaction day eszopiclone dosing n = 12 1 gm Four arm, Pbo, E; D; E + D; No PK interaction loading then 0 . 25 seven day dosing n = 12 Ketoconazole 400 Three way crossover, E; K; E + K 125% five day dosing n = 18 eszopiclone AUC and 43% Cmax and 13% ketoconazole AUC lunesta and Study 190-015 was a single centre four way crossover evaluation of the potential pharmacodynamic interaction between eszopiclone and ethanol .
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