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NALTREXONE safety information

naltrexone Naltrexone is metabolized mainly to 6?-naltrexol by the liver enzyme dihydrodiol dehydrogenase .
Other metabolites include 2-hydroxy-3-methoxy-6?-naltrexol and naltrexone 2-hydroxy-3-methoxy-naltrexone .
These are then naltrexone further metabolized by conjugation with glucuronide .
The plasma half-life of naltrexone and its metabolite 6?-naltrexol are about 4 hours and 13 hours, naltrexone respectively .
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