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Side effects
Well absorbed (90%) from rectal diazepam mucosa .
diazepam Distribution: Widely distributed .
diazepam Crosses the blood-brain barrier .
diazepam Crosses the placenta; enters breast milk .
Metabolism and Excretion: Highly metabolized by the hepatic P450 enzymes (CYP2C19 and CYP3A4); the CYP2C19 enzyme system exhibits genetic polymorphism; 15– 20% of Asian patients and 3– 5% of Caucasian and Black patients may be poor metabolizers and may have significantlyqdiazepam concentrations and diazepam an ⫽ Canadian drug name .
Contraindications/Precautions Contraindicated in: Hypersensitivity; Cross-sensitivity with other benzodiazepines may occur; Comatose patients; Myasthenia gravis; Severe pulmonary impairment; Sleep apnea; Severe hepatic dysfunction; Pre-existing CNS depression; Uncontrolled severe pain; Angle-closure glaucoma; Some products contain alcohol, propylene glycol, or tartrazine and diazepam should be avoided in patients with known hypersensitivity or intolerance; OB:qrisk of congenital malformations; Pedi: Children ⬍6 mo (for oral; safety not established); Lactation: Recommend to discontinue drug Use Cautiously in: Severe renal impairment; History of suicide attempt or drug dependence; Debilitated patients (dose p required); Patients with low albumin; Pedi: Metabolites can accumulate in neonates .
Injection contains benzyl alcohol which can cause potentially fatal gasping syndrome in neonates; Geri: Long-acting benzodiazepines cause prolonged sedation in the valium vs xanax valium pill image diazepam high length valium to ativan valium dosage for anxiety elderly .
Appears on Beers list and is associated withqrisk of falls (pdose required or consider valium tablets uk how long does it take for diazepam 5mg to work what is valium used to treat valium short-acting benzodiazepine) .
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