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The elevated levels of cytokines and chemokines can valium dosage 20 mg diazepam prescription diazepam bp 10mg valium dosage medscape diazepam high promote and amplify the inflammatory response [2] .
These cytokines and chemokines are generally proteins, in addition to the low-molecular weight diazepam lipids derived from arachidonic acid, are playing an important proinflammatory role .
In addition to this, gases like nitric oxide and carbon monoxide are recognized also as inflammatory diazepam mediators [3] .
Experimental and clinical evidences suggested that benzodiazepines could influence immune cell properties, such as phagocyte activity, chemotaxis and the production of superoxide, and cytokines; either by reducing the stress and anxiety or through stimulation of Peripheral Benzodiazepine valium high no tolerance diazepam pediatric dose diazepam pediatric dose diazepam pills 5mg diazepam Receptors (PBRS) [4] .
These PBRS have been identified mainly into the mitochondria of non-neuronal peripheral cells as adrenocortical cells [5] and also, in the cellular components of the diazepam immune system, such as monocytes, neutrophils, macrophages [6] .
Ligands of PBRs have been found to regulate activity of genes responsible for biosynthesis of cholesterol derivatives as corticosterone modulate monocyte diazepam functions such as chemotaxis [7,8] .
Also, these ligands have been reported to suppress the production valium pill blue valium used for vertigo half life ativan versus valium diazepam 5 mg rectiole of IL-1, IL-2, IL-6, TNF-α, IFN-γ, and to increase glucocorticoid production [9] .
Therefore, this study aims to investigate the possible diazepam anti-inflammatory effects of the diazepam on acute and chronic inflammatory responses in the rats with exploring the possible underlying mechanisms involved in these anti-inflammatory actions .

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